COVID-19 Vaccines Explained
As we in the U.S. struggle to set up systems for the rapid administration of SARS-CoV-2 vaccinations, what do nurses need to know about these vaccines?
Two vaccines have received emergency use authorization (EUA) in the U.S.—one manufactured by Pfizer/BioNTech, the other by Moderna. (A third, manufactured by AstraZeneca, is likely to receive EUA by April.) New, more efficient vaccine technologies along with a huge financial investment by the U.S. government have produced these products in a much shorter time frame than has been typical for other vaccines.
Currently available vaccines.
The two vaccines that are available now are messenger RNA, or mRNA, vaccines. This type of vaccine has been developed and studied for decades for possible use in preventing influenza, Zika, and other infectious diseases. Human mRNA is a strand of genetic material used for cell building and maintenance. For SARS-CoV-2 vaccines, mRNA based on part of the SARS-CoV-2 genome is synthesized and standardized in a lab.
When administered in a vaccine, this mRNA delivers to our cells the instructions to replicate a “spike protein” found on the surface of the SARS-CoV-2 virus. (Important to know and tell patients: The mRNA never enters the nuclei of our cells, and can’t be incorporated into our own DNA.) After a cell follows these instructions and “posts” the spike protein replica on its surface, the immune system recognizes it as […]