Tuberculosis: Nurses Play Critical Role in Prevention, Diagnosis, Treatment

Mantoux skin test/CDC PHIL

In the U.S., the chances are that tuberculosis isn’t on your mind a lot. Most of us focus on TB only when we have a patient on airborne precautions—or when we’ve been exposed to TB at work.

Globally, TB was one of the top 10 causes of death in 2015. In the U.S., after a spike in cases early in the HIV epidemic, the incidence of TB has fallen to about three cases per 100,000 people. In TB-endemic countries, incidence rates run into hundreds per 100,000. But with TB elimination defined as a rate of less than one case per million people, we are far from eradicating this disease in the U.S. In fact, the number of TB cases in the U.S. rose slightly from 2014 to 2015.

Also, of course, nurses often work with people who are at high risk of acquiring TB—transplant recipients, others who are immunocompromised, people with HIV or certain cancers, those who are refugees or homeless—increasing our own risk for the disease as well. Therefore, the low overall U.S. incidence rate doesn’t reflect the experience (or risk) of most nurses. (And if you are “PPD positive,” click here for some reminders about what that should mean to you as a nurse: “Nurses and Latent TB Infection.”) […]

A Status Update for World AIDS Day

Photo of AJN editor-in-chief Shawn KennedyIn light of the recent focus on Zika virus and the last few years’ attention to Ebola, there’s been little attention to HIV/AIDS. Today, December 1, World AIDS Day, is a good time to remember that millions still suffer from this disease and thousands contract it annually.

According to the MMWR report released last week by the Centers for Disease Control and Prevention (CDC), the statistics are still sobering:

  • Globally, over 36 million people have AIDS and 2.1 million were newly infected in 2015; 1.1 million died.
  • In the United States in 2013, approximately 1.2 million people had an AIDS diagnosis; approximately 44,000 were newly diagnosed in 2014.

There is good news, in that global access to treatment has increased greatly—in 2010, 7.5 million had access to antiretroviral treatment; by June 2016, over 18 million had access to antiretrovirals.

It’s been over 35 years since AIDS was first reported by the CDC—you can read an overview of the CDC’s response here. I recall the AIDS epidemic only too well. As I wrote in an editorial in 2010:

In 1975, while attending graduate school, I worked part time as a chemotherapy nurse for a hematologist in New York City. Because of his expertise, he was increasingly being asked to consult on cases involving seemingly healthy young men, most of them gay, who were contracting infections […]

The Real and Evolving Threat of Superbugs: A Primer

pillsinspaceJust how super is the latest superbug? The good news is that the infected U.S. patient has recovered. The bad news:  mcr-1, the resistance gene identified in this strain of E. coli, has brought us another frightening step closer to a “post-antibiotic” era.

In recent years, antimicrobial resistance among Gram-negative bacteria (E. coli, Klebsiella, Pseudomonas, Acinetobacter, Salmonella, and others) has been a growing public health concern. Most of the increase in resistance has been the result of mobile genetic elements that can easily transfer resistance from one bacterium to another, allowing bacteria to “catch” antibiotic resistance from one another.

To make matters worse, resistance enzymes are often packaged together. One genetic “cassette” can carry multiple resistance determinants, thereby spreading resistance to more than one class of antibiotics at the same time.

Early on, we relied on the carbapenem class of antibiotics to treat infections caused by multidrug-resistant (MDR) organisms such as the “ESBLs” (extended-spectrum beta-lactamase-producing organisms). But carbapenemase-producing organisms soon developed, and resistance to carbapenems spread quickly.

In 2009, the emergence of a “super” kind of carbapenem resistance gene, ndm-1 (New Delhi metallo-beta-lactamase) was found to be highly resistant to many antibiotic classes, including:

  • the carbapenems and other beta-lactams (penicillin derivatives and cephalosporins)
  • the fluoroquinolones (ciprofloxacin, levofloxacin, et al)
  • the aminoglycosides (gentamicin, amikacin, et al).

These antibiotic classes include the main drugs used to treat Gram-negative infections.

Et tu, […]

Zika Virus Update: Epidemiology, Sexual Transmission, Pregnancy

By Betsy Todd, MPH, RN, CIC, clinical editor

A close view of a repellent product being sprayed on a person's hand in Brasilia, Brazil, 27 January 2016. The Brazilian government announced that repellent products will be given for free to pregnant women registered in the assistance programs to avoid Zika contagion. EPA/FERNANDO BIZERRA JR. Mosquito repellant being sprayed on a person’s hand in Brazil. EPA

Zika virus is now being actively transmitted in 42 countries, primarily in the Americas and on islands in the South Pacific. As of April 13th, there had been 358 travel-associated cases reported in the U.S., including 31 pregnant women.

While there are as yet no locally acquired U.S. cases, local transmission has been established in several U.S. territories (primarily, Puerto Rico). Travel-associated cases are expected to continue in the U.S., almost certainly leading to eventual limited local transmission.

Transmission. Most cases of Zika virus infection have been vector-borne—that is, they resulted from the bite of an infected mosquito. Other modes of transmission […]

What to Know About Zika Virus

By Shawn Kennedy, AJN editor-in-chief. Accompanying map via PAHO/WHO.

The media is full of headlines and photos about the recent increase in the number of Brazilian children born with microcephaly, thought to be due to maternal exposure to the Zika virus. If you’re like most nurses, you’ve had family members and friends asking you about it, especially if they’re considering a winter escape to the Caribbean or Mexico. Here are some resources and information to help you stay up to date so you can provide your patients (and families and neighbors) with evidence-based information.


Zika basics. Zika virus was first discovered in 1947 in monkeys in the Zika forest of Uganda and the first documented case in humans was in 1952. An outbreak on Yap Island in Micronesia in 2007 showed that it had spread beyond Africa. The virus is spread by the Aedes mosquito, the same mosquito that transmits yellow fever, dengue, and chikungunya.

Outbreaks of Zika have been spreading northward from Brazil through the Americas since 2014. (See above PAHO/WHO map of confirmed cases, 2015-2016.) While most transmission is believed to occur via mosquito bites, according to the CDC, “Perinatal, in utero, and possible sexual and transfusion transmission events have also been reported. Zika virus RNA has been identified in asymptomatic blood donors during an ongoing outbreak.”

Symptoms and course are similar to those of other viruses: a few days […]

2016-11-21T13:01:31+00:00 January 26th, 2016|infectious diseases, nursing perspective|0 Comments